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The VDR necessary protein binds to vitamin D in its active form, calcitriol, and partners with another gene-regulating protein known as retinoid A receptor (RXR). Together they will bind to particular regions of DNA often known as vitamin D response elements, turning these genes on or perhaps off. These types of genes help control the availability of necessary protein such as calcium and phosphate in cellular material, and also influence other operations, such as growth of hair. In addition , a number of VDR polymorphisms have been completely associated with our diseases and other traits. However , most of the molecular mechanisms that determine whether VDR binds to specific genes remain to become fully appreciated.